fMRI-TMS for those with Bipolar Disorders

fMRI-TMS Proves Greater Wellness for those with Bipolar Disorder

Bipolar disorder, also known as manic-depressive illness, is a brain disorder that causes unusual shifts in mood, energy, activity levels, and the ability to carry out day-to-day tasks.

There are four basic types of bipolar disorder; all of them involve clear changes in mood, energy, and activity levels. These moods range from periods of extremely “up,” elated, and energized behavior (known as manic episodes) to very sad, “down,” or hopeless periods (known as depressive episodes). Less severe manic periods are known as hypomanic episodes.

Types of bipolar disorder

Bipolar I Disorder

Bipolar I Disorder is defined by manic episodes that last at least 7 days, or by manic symptoms that are so severe that the person needs immediate hospital care. Usually, depressive episodes occur as well, typically lasting at least 2 weeks. Episodes of depression with mixed features (having depression and manic symptoms at the same time) are also possible.

Bipolar II Disorder

Bipolar II Disorder is defined by a pattern of depressive episodes and hypomanic episodes, but not the full-blown manic episodes described above.

Cyclothymic Disorder

Cyclothymic Disorder (also called cyclothymia) is defined by numerous periods of hypomanic symptoms as well numerous periods of depressive symptoms lasting for at least 2 years (1 year in children and adolescents). However, the symptoms do not meet the diagnostic requirements for a hypomanic episode and a depressive episode.

Other Specified and Unspecified Bipolar and Related Disorders

Other specified and unspecified bipolar and related disorders are defined by bipolar disorder symptoms that do not match the three categories listed above.

Open-label and sham-controlled clinical trials using TMS for the treatment of bipolar mania have shown significant improvements in symptoms1-4. With fMRI imaging, we can identify the network(s) not functioning properly that causes these manic episodes to occur. With this technology, we can treat the specific areas precisely with a personalized treatment plan and precise Neuronavigation.


1. Praharaj SK, Ram D, Arora M. Efficacy of high frequency (rapid) suprathreshold repetitive transcranial magnetic stimulation of right prefrontal cortex in bipolar mania: a randomized sham controlled study. J Affect Disord 2009;117:146–150.

2. Grisaru N, Chudakov B, Yaroslavsky Y, et al. Transcranial magnetic stimulation in mania: a controlled study. Am J Psychiatry 1998;155:1608–1610.

3. Michael N, Erfurth A. Treatment of bipolar mania with right prefrontal rapid transcranial magnetic stimulation. J Affect Disord 2004;78:253–257.

4. Saba G, Rocamora JF, Kalalou K, et al. Repetitive transcranial magnetic stimulation as an add-on therapy in the treatment of mania: a case series of eight patients. Psychiatry Res 2004;128:199–202.

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