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GMA3 – March 12, 2024

A look at our correspondent’s brain on sugar

Dr. Jen Ashton, ABC News correspondent Phil Lipof, and Dr. Nicole Avena discuss how to curb sugar cravings, and look at Lipof’s brain before and after consuming sugar.


Patented Technologies


Targeted and individualized methods are provided herein for determining specific treatment sites based on an individual patient. Embodiments described herein may use functional and/or structural connections to create brain mapping of the patient and/or control groups having the same metrics as the patient, and combinations thereof in determining target locations for stimulation treatment.

A crown sits atop the words "columbia university" on a white field
A red O sits atop the words The Ohio State University
A drawing of new york state sits next to the logo for the new york state psychiatric institute
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  • Landa A, Wang Z, Russell JA, Posner J, Duan Y, Kangarlu A, Huo Y, Fallon BA, Peterson BS.: Distinct neural circuits subserve interpersonal and non-interpersonal emotions.. Soc Neurosci. 2013;8: 474-88
  • Colibazzi T, Posner J, Wang Z, Gorman D, Gerber A, Yu S, Zhu H, Kangarlu A, Duan Y, Russell JA, Peterson BS.: Neural systems subserving valence and arousal during the experience of induced emotions.. Emotion 2010;10: 377-89
  • Liu F, Garland M, Duan Y, Stark RI, Xu D, Bansal R, Dong Z, Peterson BS, Kangarlu A.: Techniques for in utero, longitudinal MRI of fetal brain development in baboons at 3T.. J Magn Reson Imaging 2009;29: 13-22
  • Kangarlu A.: High-field magnetic resonance imaging. Neuroimaging Clin N America 2009;19: 113-28
  • Posner J, Russell JA, Gerber A, Gorman D, Colibazzi T, Yu S, Wang Z, Kangarlu A, Zhu H, Peterson BS.: The neurophysiological bases of emotion: An fMRI study of the affective circumplex using emotion-denoting words. Hum Brain Mapp. 2009;30: 883-95

Marta Moreno-Ortega – Columbia University

Failure of deactivation in bipolar disorder during performance of an fMRI adapted version of the Stroop task
N Verdolini, M Moreno-Ortega, P Salgado-Pineda, G Monté, …
Journal of Affective Disorders 329, 307-314
1 2023

Activation and deactivation patterns in schizophrenia during performance of an fMRI adapted version of the stroop task
P Salgado-Pineda, R Rodriguez-Jimenez, M Moreno-Ortega, …
Journal of Psychiatric Research 144, 1-7

Frequency drift in MR spectroscopy at 3T
SCN Hui, M Mikkelsen, HJ Zöllner, V Ahluwalia, S Alcauter, L Baltusis, …
NeuroImage 241, 118430

Parcel-guided rTMS for depression
M Moreno-Ortega, A Kangarlu, S Lee, T Perera, J Kangarlu, T Palomo, …
Translational psychiatry 10 (1), 283

Comparison of multivendor single-voxel MR spectroscopy data acquired in healthy brain at 26 sites
M Považan, M Mikkelsen, A Berrington, PK Bhattacharyya, MK Brix, …
Radiology 295 (1), 171-180

Big GABA II: Water-referenced edited MR spectroscopy at 25 research sites
M Mikkelsen, DL Rimbault, PB Barker, PK Bhattacharyya, MK Brix, …
Neuroimage 191, 537-548

Resting state functional connectivity predictors of treatment response to electroconvulsive therapy in depression
M Moreno-Ortega, J Prudic, S Rowny, GH Patel, A Kangarlu, S Lee, …
Scientific reports 9 (1), 5071

Integrative Analysis of GABA-Edited MRS Data Acquired at 24 Research Sites
M Mikkelsen, PB Barker, PK Bhattacharayya, MK Brix, PF Buur, KM Cecil, …
International Society for Magnetic Resonance in Medicine, Date: 2017/04/22 …

Neural systems subserving valence and arousal during the experience of induced emotions.
T Colibazzi, J Posner, Z Wang, D Gorman, A Gerber, S Yu, H Zhu, …
Emotion 10 (3), 377

The neurophysiological bases of emotion: An fMRI study of the affective circumplex using emotion‐denoting words
J Posner, JA Russell, A Gerber, D Gorman, T Colibazzi, S Yu, Z Wang, …
Human brain mapping 30 (3), 883-895

An affective circumplex model of neural systems subserving valence, arousal, and cognitive overlay during the appraisal of emotional faces
AJ Gerber, J Posner, D Gorman, T Colibazzi, S Yu, Z Wang, A Kangarlu, …
Neuropsychologia 46 (8), 2129-2139

Cognitive, cardiac, and physiological safety studies in ultra high field magnetic resonance imaging
A Kangarlu, RE Burgess, H Zhu, T Nakayama, RL Hamlin, AM Abduljalil, …
Magnetic resonance imaging 17 (10), 1407-1416

Effect of static magnetic field exposure of up to 8 Tesla on sequential human vital sign measurements
DW Chakeres, A Kangarlu, H Boudoulas, DC Young
Journal of Magnetic Resonance Imaging: An Official Journal of the …

Human magnetic resonance imaging at 8 T
PML Robitaille, AM Abduljalil, A Kangarlu, X Zhang, Y Yu, R Burgess, …
NMR in Biomedicine: An International Journal Devoted to the Development and …

Big GABA: Edited MR spectroscopy at 24 research sites
M Mikkelsen, PB Barker, PK Bhattacharyya, MK Brix, PF Buur, KM Cecil, …
Neuroimage 159, 32-45

Biological effects and health implications in magnetic resonance imaging
A Kangarlu, PML Robitaille
Concepts in Magnetic Resonance: An Educational Journal 12 (5), 321-359

Our Research

We are interested in enhancing capabilities of MRI in accessing cellular level information about the structure and function of the human brain. For example, while within the cerebral cortex, sulci and gyri constitute the most identifiable anatomical landmarks, functional organization of the cortex is not yet accessible. The MRI-visible structural units within the cortex, which are function-related are the cortical areas and subcortical nuclei. The spatial resolution of MRI is sufficient to visualize these structures. The depiction of internal structure and interfaces of these units, however, requires much higher resolution. To enable MRI to characterize brain structure and function more precisely requires more technological advancement in information encoding (pulse sequences) and detection (RF coils). Our past high-resolution images indicate that the opportunity exists to enhance the sharpness of areal and nuclear borders to acquire microscopic cytoarchitectonic MRI maps in-vivo non-invasively. Considering that high susceptibility will amplify both physical representation and hemodynamic representation of microscopic vessels, we are interested in developing techniques to exploit this effect to offer more direct access to neural activity (fMRI). We are interested in using this aspect of high magnetic field to sensitize MRI to neurochemical activities.

Physics and engineering techniques are used to develop radio frequency (RF) coils to enhance the sensitivity of MRI in obtaining more accurate information from the human brain. Every MRI technique including high resolution anatomical, fMRI, DTI, spectroscopy, and perfusion are used to study the brain both in normal state and stimulated state. Minute variation in the brain of patients with psychiatric disorders as a response to our imaging techniques are analyzed to extract information about the inner structure and function of the brain. In addition, pulse sequences are developed to enable us to better detect metabolites, response to motor/sensory or cognitive tasks, and neuronal tracks.


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The blog aims to provide readers with valuable information, insights, and resources to better understand and utilize neurotherapy for enhancing brain health and optimizing mental well-being.

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